The relationship between left ventricular diastolic function and arterial stiffness of diabetes patients

Abstract

Objective To investigate the association between left ventricular diastolic function and arterial stiffness in patients with type 2 diabetes mellitus. Methods One hundred and two patients with type 2 diabetes（ diabetic group）,and 126 non-diabetic patients（ control group） were selected from Jan. 2012 to Dec. 2013 in the Beijing Military General Hospital. The clinical features were recorded and free blood glucose （FBG ）,blood lipids were measured. Cardio ankle vascular index（ CAVI ） was measured by VS-1000 arteriosclerosis detector. Ultrasound heartbeat diagram was used to determine the left ventricular diastolic function indexes including the left atrial diameter（LAD）,left ventricular early diastolicpeak velocity（E）,left ventricular diastolic peak velocity（A）,E/ A ratio and E peak deceleration time（EDT）. Results The level of LAD,A, EDT,CAVI in diabetic patients were（39. 5 ± 5. 3）mm,（76. 6 ± 13. 5）cm/ s,（206. 6 ± 56. 3）ms,（9. 6 ± 1. 1）respectively,higher than those in control group（（34. 4 ± 4. 2）mm,（71. 3 ± 13. 4）cm/ s,（185. 5 ± 34. 4）ms,（8. 5 ± 0. 9））. And E,E/ A level in diabetic group were（56. 6 ± 20. 4）cm/ s and（0. 73 ± 0. 21）,significantly lower than the control group（（67. 5 ± 16. 4）cm/ s and（0. 96 ± 0. 26））. The differences between the two groups were significant（P = 0. 001,0. 004,0. 002,0. 001,0. 001,0. 001）. After adjusting the factors including body mass index and triglyceride,CAVI was negatively correlated with E/ A（r = - 0. 339,P〈 0. 05））and positively correlated with EDT（r = 0. 314,P 〈 0. 05）. Conclusion The diabetic patients with lower diastolic function and higher arterial stiffness,and the two factors are negatively correlation. Key words: Diabetes; Cardiac diastolic function; Arterial stiffness; Cardio ankle vascular index