Abstract
Background: Adherence is one of the most critical factors in the success of pulmonary tuberculosis therapy. Non-compliance of patients taking anti-tuberculosis drug results in a high rate of treatment failure, increasing the risk of disease severity and death.
 Objective: This study aims to investigate the impact of knowledge level on patient compliance in taking anti-tubercular medication.
 Methods: This observational, cross-sectional study employed a total sampling method. The levels of knowledge and compliance were assessed using a validated questionnaire administered to patients with pulmonary tuberculosis at the Pekalongan City health center (Puskesmas).
 Results: Among the 52 participants, 44.23% (n=23) demonstrated a high level of knowledge, and 86.5% (n=45) exhibited good compliance. Spearman correlation test analysis revealed a significant influence of knowledge level on patient compliance in taking antituberculosis drugs (p=0.001, r=0.341), indicating that higher knowledge levels correspond to better patient compliance.
 Conclusion: The study suggests that patient compliance with antitubercular medication improves as knowledge level increases.
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