Abstract

Tuberculosis (TB) remains the highest priority among infectious diseases in the world today with increasing morbidity and mortality every year. Adherence to treatment plays an important role in the success of therapy among TB patients. This study aims to explore the relationship between demographic characteristics, knowledge, and medication compliance behavior among patients with tuberculosis in Indonesia. This study was descriptive correlational and cross-sectional design with the total sample was 150 tuberculosis confirmed in Medan Pulmonary Hospital, Indonesia. In this study found that there is a significant relationship between ethnicity and medication adherence (continues variable) with p = 0.01. Meanwhile when medication compliance behavior was treated as categorical variables, a significant relationship was found between medication compliance behavior and medical history (p = 0.03), smoking (p = 0.005), and alcohol (p = 0.03) among tuberculosis patients in Indonesia. In the multivariate analysis, multiple linear regression was performed which surprisingly shows that education was significantly associated with knowledge of TB (p = 0,02), and ethnicity (0.04).

Highlights

  • The World Health Organization (WHO) ranks tuberculosis as the top priority among infectious diseases in the world today

  • Well over half of the participants stated that they did not have a medical history of longterm disease such as diabetes or tuberculosis (n = 91, 60.7%), and ironically, 33% of them were still smoking while taking medication, and 16.7% were still drinking alcohol while on medication

  • This study found that the medical history of chronic illness was significantly associated with medication adherence of tuberculosis patients in Indonesia

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Summary

Introduction

The World Health Organization (WHO) ranks tuberculosis as the top priority among infectious diseases in the world today. According to WHO data, in 2018, tuberculosis was among the top 15 death by cause with over one million patients.[28]. In 2016, the estimated incidence of tuberculosis was 10.4 million cases, equivalent to 120 per 100,000 persons. The countries with the highest incidence of tuberculosis are India, China, Indonesia, Nigeria, and Pakistan, in that order. In Indonesia, the number of new cases of tuberculosis reached 420,994 in 2018, with a prevalence rate of 297/100,000 and an incidence rate of 403/100,000 people. In 2017 there were more than 1,000 reported deaths from tuberculosis in Indonesia, which means 189 deaths per 100,000 persons. There were 3 cases among men for every 1 woman newly diagnosed with the disease.[6]

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