Abstract
AimTo analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress in gestational diabetes mellitus (GDM).MethodsFrom January to November 2019, 75 patients with GDM were selected as GDM group, according to age of 1:1; 75 normal pregnant women were selected as Control group. Blood glucose, insulin, stress hormones such as cortisol, norepinephrine (NE), and epinephrine (E), and iron metabolism index such as serum iron, serum ferritin (SF), and transferrin saturation (TS) were measured. Insulin resistance was evaluated by homeostasis model insulin resistance index (HOMA-IR). Multiple linear regression was used to analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress.ResultsThe levels of NE, E, serum iron, SF, and TS saturation in the GDM group were higher than Control group (t = 3.82, 2.75, 3.14, 6.12, and 3.90, P < 0.05, <0.05, <0.05, <0.01, <0.01); HOMA-IR was higher in the GDM group (t = 4.92, P < 0.01); malondialdehyde (MDA) was higher, while superoxide dismutase (SOD) was lower than Control group (t = 5.25, 4.98, both P < 0.01). Epinephrine, norepinephrine, cortisol, and serum ferritin were positively correlated (r = 0.21, 0.17, and 0.21); epinephrine, cortisol, and transferrin were positively correlated (r = 0.12, 0.31). There was a positive correlation between HOMA-IR and SF and TS (r = 0.34, 0.34). MDA was positively correlated with SF and TS (r = 0.24, 0.29); SOD was negatively related to SF and TS (r = −0.12, −0.17).ConclusionsIron metabolism index is related to insulin resistance in GDM women. The change in iron metabolism may be involved in the pathogenesis of gestational diabetes caused by stress- adaptive disorder.
Highlights
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first occurrence during pregnancy[1]
Oxidative stress Compared with Control group, MDA in GDM group is increased (P < 0.01); superoxide dismutase (SOD) is decreased in GDM group, and the difference is statistically significant (P < 0.01), and GSH is decreased slightly, but the difference is not statistically significant (P > 0.05) (Table 2)
E, NE, and cortisol are dependent variables; after body mass index (BMI) correction, the results showed that serum ferritin (SF) is positively related to E, NE, and cortisol (P < 0.05) in GDM group; the same trend occurred in Control group, but there is no significant difference (P > 0.05) (Table 4)
Summary
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first occurrence during pregnancy[1]. The change in stress hormones can affect the iron transport process; serum iron is positively related to insulin and blood glucose, suggesting that iron overload may be a risk factor for increased risk of diabetes[5,6]. Iron overload may have a close relationship with the risk of hyperglycemia by affecting the degree of oxidative stress injury in the body[7]. The purpose of this study is to analyze the relationship between iron metabolism index and stress hormones, insulin resistance, and oxidative stress in GDM women, so as to provide new clues for the pathogenesis of GDM
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
