Year-end Sale % OFF 
Abstract
Solubilities and intrinsic dissolution rates for alaproclate hydrochloride, oxazepam and dextropropoxyphene napsylate have been determined in binary mixtures of water and ethanol. On a log-log scale, a linear relationship between the solubilities and the corresponding intrinsic dissolution rates with a slope of 1.0 was found. A solubility range of four log-units was covered. However, dextropropoxyphene napsylate in pure ethanol appeared to diverge from this relationship. This was explained by a change in crystalline form as indicated by differential scanning calorimetry. By calculating the solubility in ethanol before the crystal form changed, a better fit for the solubility-intrinsic dissolution rate relationship was obtained.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
