The relationship between interferon-gamma (INF-γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis

Abstract

ABSTRACT Objective: This meta-analysis was designed to investigate the association between interferon-gamma (IFN-γ) polymorphisms and occurrence risk of aplastic anemia. Methods: Literature search was conducted in PubMed, Embase and Cochrane Library up to April 2018. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by R 3.12. Results: Total five studies with 304 aplastic anemia patients and 588 controls were included. The statistically significant results were found in the following models: allele genetic model (T vs A: OR = 2.1749, 95% CI = 1.6825–2.8114, P < 0.01), additive genetic model (TA vs AA: OR = 2.1071, 95% CI = 1.3962–3.1799, P < 0.01; TT vs AA: OR = 4.5788, 95% CI = 2.6606–7.8797, P < 0.01), recessive genetic model (TT vs AA + TA: OR = 2.5579, 95% = 1.6680–3.9226, P < 0.01), dominant genetic model (TT + TA vs AA: OR = 2.5599, 95% = 1.7424–3.7611, P < 0.01), the results suggested that the increased occurrence risk of aplastic anemia is significantly associated with the IFN-γ polymorphism. Conclusions: Patients with IFN-γ genotype carrying allele T have higher occurrence risk of aplastic anemia.