Abstract
Objective: The study was investigate serum zinc (Zn), chromium (Cr), cobalt (Co) and manganese (Mn) concentrations in relation to hormone levels and polycystic ovary syndrome (PCOS).Materials and Methods: Fourty women between 18-40 years of age diagnosed with PCOS. We also seleceted 40 healty volunteers as the control group. Serum Zn, Cr, Mn, follicular stimulating hormone (FSH), luteinizing hormone(LH), Dehydroepiandrosterone sulfate (DHEA-S), total testosterone (TT), sex hormone binding globulin (SHBG), insulin, glucose, cholesterol, triglyceride, High Density Lipoprotein (HDL-C) and Low density lipoprotein (LDL-C) concentrations were determined. Results: Insulin, glucose, triglyceride, DHEA-S levels were significantly higher in the PCOS group than in the control group, while FSH and Mn levels were significantly lower in the HOMA-IR group than in the control group (p< 0.05). Conclusions: A possible association is perceptible in our study between some of serum trace elements and women with PCOS. The association attains a connotative level with the involvement of IR in it. Additional studies evaluating the effects of these elements supplementation would be required to confirm the hypothesis as well as to ascertain whether insulin resistance in the presence of manganese deficiency can directly lead to oxidative stress.
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