Abstract
Background Infant colic is a common benign disease during early infancy. Migraine and tension-type headache (TTH) are the most common primary headache forms among pediatric population. Several studies have investigated the incidence of infant colic in patients with migraine and TTH. The meta-analysis was to assess the relationship between infant colic and migraine as well as TTH. Methods PubMed, Web of Science, and Cochrane Library were searched until August 16, 2018, for potential studies. Data were extracted by two independent authors and analyzed using RevMan 5.2 software. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine the association between infant colic and migraine as well as TTH, respectively. Results A total of 148 studies were found, and 7 studies were finally included. A higher incidence of colic during infancy was revealed in migraine patients than controls (P=0.05, OR: 2.51, 95% CI: 1.32–4.77) and TTH subjects (P=0.02, OR: 0.33, 95% CI: 0.13–0.86), respectively. And no significances were found between TTHs with controls (P=0.51, OR: 1.17, 95% CI: 0.73–1.89). Conclusion This meta-analysis indicated that migraine was associated with increased incidence of infantile colic history, but TTH incidence was not relevant with the incidence of infantile colic history.
Highlights
Infantile colic is a benign disease during the first months of life and is one of the most distressing challenges for parents [1]
A systematic literature search was done in PubMed, Web of Science, Cochrane Library, and EMBASE until April 5, 2018, to detect the studies assessing the relationship between infantile colic and migraine as well as TTH. e search terms used to retrieve relevant publications included the following in various combinations: “pediatric Odds ratios (ORs) child OR children OR infant OR infantile” and “migraine OR headache OR tension-type headache.”
Studies fulfilling the following requirements were included: (1) a diagnosis of colic within 3 months old, (2) clinical articles, and (3) full record of the incidence of infant colic in migraine or detailed information could be retrieved through contacting the authors. e diagnosis of migraine and TTH were defined according to the criteria of the International Classification of Headache Disorders III; (ICHD III;) [17]
Summary
Infantile colic is a benign disease during the first months of life and is one of the most distressing challenges for parents [1]. It is estimated that it affects 10% to 40% of the normal infant population in the world. Infant colic is a common benign disease during early infancy. Several studies have investigated the incidence of infant colic in patients with migraine and TTH. E meta-analysis was to assess the relationship between infant colic and migraine as well as TTH. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine the association between infant colic and migraine as well as TTH, respectively. A higher incidence of colic during infancy was revealed in migraine patients than controls (P 0.05, OR: 2.51, 95% CI: 1.32–4.77) and TTH subjects (P 0.02, OR: 0.33, 95% CI: 0.13–0.86), respectively.
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