The relationship between IL-6 levels and the angiographic severity of coronary artery disease following percutaneous coronary intervention in acute coronary syndrome patients

Yang Ling,Hairong Weng,Shengxing Tang

doi:10.1186/s12872-021-02406-7

Yang Ling, Hairong Weng + Show 1 more

Open Access

https://doi.org/10.1186/s12872-021-02406-7

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Abstract

BackgroundThe present investigation was developed for the exploration of the association between IL-6 levels and acute coronary syndrome (ACS) findings upon angiographic evaluation.MethodsA retrospective review of 346 patients suffering from chest discomfort that underwent coronary angiography was performed. The SYNergy between Percutaneous Coronary Intervention with TAXus and cardiac surgery (SYNTAX) score (SS) and SS II were used to gauge ACS severity, with ACS patients being stratified into two groups based on an SS value of 22 and the median SS II value. Associations between IL-6 levels and SS or SS II values were assessed through Spearman's correlation analyses, and independent predictors of intermediate-high SS or high SS II were identified via a multivariate logistic regression approach. A receiver operating characteristic (ROC) curve was employed to explore of the predictive value of IL-6 levels.ResultsIL-6 was positively correlated with both SS (r = 0.479, P < 0.001) and SS II (r = 0.305, P < 0.001). Moreover, IL-6 levels were independently predictive of intermediate-high SS and high SS II values. ROC curves further demonstrated that IL-6 was able to predict intermediate-high SS and high SS II, with area under the curve (AUC) values of 0.806 and 0.624, respectively.ConclusionIL-6 levels are closely linked to the extent of coronary artery disease in ACS patients undergoing percutaneous coronary intervention. IL-6 levels may thus serve as a valuable and non-invasive biomarker of high-risk ACS patients.

Highlights

The present investigation was developed for the exploration of the association between IL-6 levels and acute coronary syndrome (ACS) findings upon angiographic evaluation
Study population For this study, patients suffering from chest pain that were admitted to the Division of cardiology and underwent coronary angiography (CAG) between January 2021 to August 2021 were enrolled
Patients in the ACS group were mostly male and exhibited higher creatinine and fibrinogen levels (P < 0.05) relative to those of patients in the stable angina pectoris (SAP) group. These ACS patients exhibited significant increases in white blood cell (WBC), neutrophil (NEUT), and platelet counts as well as neutrophil to the lymphocyte ratio (NLR) values compared to SAP patients (P < 0.05)

Summary

Introduction

The present investigation was developed for the exploration of the association between IL-6 levels and acute coronary syndrome (ACS) findings upon angiographic evaluation. Acute coronary syndrome (ACS) is a condition that incorporates several forms of myocardial ischemia, including ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) as well as unstable angina pectoris (UA), and it is the leading cause for global morbidity and mortality [1, 2]. Links between higher IL-6 levels and an elevated risk of cardiovascular events among otherwise healthy individuals are well documented [13, 14], and IL-6 has been proposed to be a predictor of coronary artery disease (CAD) severity and associated mortality among ACS patients [6, 15, 16]. Levels of IL-6 have been reported to be associated with plaque burden as defined by intracoronary imaging [17]

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