Abstract
Aims To investigate the correlation between hypertriglyceridemic waist circumference (HTWC) phenotype and gestational diabetes mellitus (GDM). Methods A total of 1083 patients with gestational age ≤8 weeks were divided into four groups: normal triglyceride and waist circumference group (group A, n = 575), simple abdominal obesity group (group B, n = 317), simple high triglyceride group (group C, n = 125), and HTWC group (group D, n = 66). General information and serum biochemical indicators were measured and recorded. Analysis of variance (ANOVA) and logistic regression analysis were used to evaluate the relationship between HTWC with GDM. Results The prevalence of GDM in the HTWC group was significantly greater than in the other three groups. After adjustment by multivariate logistic regression analysis, the proportion of GDM in the HTWC group was 1.753 times higher than in group A. Conclusion These findings suggest that there is a significant correlation between HTWC phenotype and GDM, indicating that the HTWC phenotype could be applied as a simple marker for identifying GDM risk factors.
Highlights
Hypertriglyceridemic waist circumference (HTWC) is a simple and useful screening phenotype test for diabetes mellitus (DM) and cardiovascular diseases [1][2]
These findings suggest that there is a significant correlation between hypertriglyceridemic waist circumference (HTWC) phenotype and gestational diabetes mellitus (GDM), indicating that the HTWC phenotype could be applied as a simple marker for identifying GDM risk factors
There were no significant differences in age, systolic blood pressure (SBP), diastolic blood pressure (DBP) and family history of DM among the four groups (P > 0.05)
Summary
Hypertriglyceridemic waist circumference (HTWC) is a simple and useful screening phenotype test for diabetes mellitus (DM) and cardiovascular diseases [1][2]. It was first proposed by Isabelle Lemieux et al [3], and has attracted much attention in recent years worldwide. Many studies in China and other countries have shown that HTWC can identify patients with early risk factors for DM and predict the occurrence and development of DM [1][4]. To investigate the correlation between hypertriglyceridemic waist circumference (HTWC) phenotype and gestational diabetes mellitus (GDM)
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