Abstract
BackgroundRecently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection.MethodsThe rs9277535 and rs7453920 were genotyped in 370 subjects with chronic HCV infection, 194 subjects with spontaneous HCV clearance, and 973 subjects with non-HCV infection from the Chinese population using the ABI TaqMan allelic discrimination assay.ResultsLogistic regression analyses showed that the minor allele A of rs7453920 significantly increased the susceptibility of HCV infection in dominant model (adjusted OR = 1.33, 95% CI: 1.04–1.71, P = 0.026) and additive models (adjusted OR = 1.30, 95% CI: 1.06–1.60, P = 0.012). Rs9277535 A allele significantly increased the risk of chronic HCV infection in dominant model (adjusted OR = 1.52, 95% CI: 1.01–2.28, P = 0.046). Haplotype AA showed a higher risk of HCV infection than the most frequent haplotype GG (adjusted OR = 1.37, 95% CI: 1.05–1.78, P = 0.018).ConclusionThe HLA-DQ rs7453920 and -DP rs9277535 mutations were significantly associated with HCV infection susceptibility and chronicity, respectively.
Highlights
Human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity
Katayoun et al conducted a genome wide association study (GWAS) and found the human leukocyte antigen (HLA)-DRB1 * 0301 alleles were significantly associated with viral clearance, and DQA1 * 0201 and DQB1 * 0602 alleles are significantly associated with HCV persistence [13]
Observed genotype frequencies for rs9277535 and rs7453920 in non-HCV infection group were all in Hardy-Weinberg equilibrium (P = 0.107 for rs9277535, P = 0.114 for rs9277535, respectively)
Summary
Human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The innate and adaptive immune response after the infection of HCV, which varies across individuals, affect the susceptibility and chronicity to HCV infection [5, 6]. It is globally recognized that HLA class II molecules, categorized into three sub-regions: HLA-DR, −DQ and -DP, are key determinants in the immune response to HCV infection through the effective presentation of Tcells to viral antigens [10, 11]. Researchers have recently discovered that variation in HLA class II genes are determinants of the susceptibility and chronicity of HCV infection. Katayoun et al conducted a genome wide association study (GWAS) and found the HLA-DRB1 * 0301 alleles were significantly associated with viral clearance, and DQA1 * 0201 and DQB1 * 0602 alleles are significantly associated with HCV persistence [13]
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