Abstract
The study aimed to explore the prevalence of human adenovirus-36 (HAdV-36) infection and the association of HAdV-36 with obesity in Chinese Han population. A qualitative determination using ELISA was performed to determine by duplication of the antibodies to HAdV-36 in the serum samples. Logistic regression analysis was used to analyze the association between HAdV-36 seropositivity and obesity. The overall HAdV-36 seroprevalence was 49.8% amongst 824 participants. The prevalence of HAdV-36 seropositive was 42.9 and 51.4% in the obese and non-obese participants, respectively, which was not statistically significant (P=0.05). There were significant differences in the anthropometric and biochemical parameters observed between the two groups except for height (P=0.067) and total cholesterol (TC) (P<0.29). After the adjustment for age and gender, HAdV-36 seropositivity was a protective factor for obesity (odds ratio (OR) = 0.69, 95% confidence intervals (95% CI) = 0.48–0.97, P=0.03). In the male population, the adjusted OR for AD-36 antibody-positive status was statistically decreased for obese adults (OR = 0.59; 95% CI = 0.39–0.91; P=0.02). However, the similar result was not obtained in the female population (OR = 0.90; 95% CI = 0.48–1.67; P=0.73). We found a high prevalence of HAdV-36 infection in China and significant association between HAdV-36 infection and obesity or weight gain after the adjustment for age and gender. The HAdV-36 infection may be related to the weight loss in Chinese Han population, especially in the male group, which needs to be further confirmed.
Highlights
Environmental and genetic influences have been identified as the main factors for obesity [1,2]
Some meta-analysis reported that human adenovirus 36 (HAdV-36) infection was associated with obesity [22,23,25]
The result obtained in our research showed that the HAdV-36 infection may not cause the weight gain, which may be a protective factor for male adult obesity in Chinese Han population
Summary
Environmental and genetic influences have been identified as the main factors for obesity [1,2]. The prevalence of HAdV-36 infection in humans and the association with obesity/metabolic abnormalities were reported in different countries [8,9,10,11,12,13]. 30% of obese and 11% of non-obese humans had neutralizing antibodies to HAdV-36 which were associated with reductions in serum cholesterol and TG [14,15]. In Swedish, HAdV-36 infection was linked with children obesity, severe obesity in female adults, and lower risk of high blood lipid levels [12]. In Children, the prevalence of antibodies to HAdV-36 was higher in obese than in non-obese in U.S.A. and South Korea [18,19]
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