The relationship between homocysteine and essential hypertension in Kazakh adolescents from pasturing area of Xinjiang

Abstract

Objective To investigate the relationship between homocysteine and essential hypertension in Kazakh adolescent from pasturing area of Xinjiang.Methods We recruited 84 patients with essential hypertension(case group) and 100 controls without hypertension (control group).Fasting blood were obtained from all subjects.Then we measured the homocysteine levels in all subjects.We analyzed the relationship between homocysteine and essential hypertension in Kazakh adolescent from pasturing area of Xinjiang finally.Results After adjusting of sex,age,body mass index,and family history,compared with the control group,the homocysteine levels in case group increased and had significant difference(P ＜ 0.001).The results of Logistic regression analysis suggested that after adjusting of sex,age,body mass index,and family history,the OR value of essential hypertention increased with homocysteine(OR =10.23,P ＜ 0.001).Positive correlation existed between plasma homocysteine levels and systolic blood pressure(r =0.722,P ＜ 0.001),and diastolic blood pressure (r =0.534,P ＜0.001) after adjusted of sex,age,body mass index,and family history by using partial correlation analysis.Conclusion In Kazakh adolescent from pastoral areas of Xinjiang,homocysteine was associated with essential hypertension and blood pressure level.The higher homocysteine level was an independent risk factor for essential hypertension in Kazakh adolescent from pasturing area of Xinjiang. Key words: Kazakh; Children; Essential hypertension; Homocysteine