Abstract
ABSTRACTThis prospective analysis assessed the effect of histological prostatitis on lower urinary tract functions and sexual function. The patients were separated into two groups as histologically observed prostatitis (Group A) and no prostatitis (Group B) according to the biopsy outcomes. International prostate symptom score, international index of erectile function-5 scores, maximal and average flow rate, and residual urine volumes were compared statistically between groups. There was no significant difference (P>0.05) in baseline age (t=0.64), body mass index value (t=0.51), prostate volume (t=0.87), prostate-specific antigen levels (t=0.43), maximal (t=0.84) and average flow rate (t=0.59), and post-void residual urine volume (t=0.71). Mean international prostate symptom score in patients with prostatitis was numerically but not significantly higher than that in those without prostatitis (t=0.794, P=0.066). Mean international index of erectile function-5 score in the prostatitis group was significantly lower than that in those without prostatitis (t=1.854, P=0.013). Histological prostatitis notably affected sexual function of patients and may serve as a major risk factor for sexual dysfunction while having little effect on lower urinary tract symptoms.
Highlights
Histological prostatitis corresponds to prostatic inflammation confirmed by microscopic examination
Of patients included in the study (n=104), 34.6% had histological prostatitis (Group A) and 65.4% had none (Group B)
There was no significant difference in age, body mass index (BMI), prostate volume, PSA, Qmax, Qavg and post-void residual urine volume (PVR) (Table-1)
Summary
Histological prostatitis corresponds to prostatic inflammation confirmed by microscopic examination. The typical histologic finding of prostatitis is characterised by infiltration of the prostatic ductus and periprostatic tissue, especially with polymorphic nuclear leukocytes [1, 2]. Histological prostatitis is frequently detected in biopsy of prostate specimens during surgery or autopsy. A prostate autopsy study found inflammation in 40 of 91 adults patients [3]. Maksem et al have reported evidence of prostatic inflammation in 45% of aspiration biopsy specimens taken because of suspicion of carcinoma [4]. Even though inflammatory cells in prostate tissue are a well-reported observation, there is no precise information about the origin of inflammation, which is thought to be multifactorial [5]
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