Abstract
As the development of the times and scientific progress, people's material culture has been enhanced. We pay attention to not only the material pursuing but also spiritual enjoyment. However, Alzheimer's disease affects the quality of late-life significantly. Congnitive disorder is one clinical symptom of Alzheimer's disease, which influences people's later life the most. β-amyloid (Aβ) plaques accumulation, tau protein hyperphosphorylation, nerve vascular dysfunction, abnormal cell cycle, inflammation, oxidative stress, and mitochondrial disorder may be the pathogenesis of Alzheimer's disease. The inflammation of Alzheimer's disease can be caused by the nervous lesions that are generated by the inflammatory mediator released by activated neurogliocyte around Aβ. High mobility group-B1 (HMGB1) and receptor for advanced glycation endproducts (RAGE) are closely related to the inflammation. It may also promote the progresses of Alzheimer's disease, if HMGB1 is combined with RAGE. This review aims to elaborate the relationship between HMGB1/RAGE and Alzheimer's disease. Key words: High mobility group proteins/ME; Glycosylation end products, advanced/ME; Alzheimer disease/ME; Review
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