The relationship between HIF-2α with the prognosis of colorectal cancer

Abstract

Objective To observe the changes of HIF-2α in Han and Tibetan with colorectal cancer in Qinghai province. To analyze the relationship between the HIF-2α and the prognosis of colorectal cancer. Methods 120 patients with colorectal cancer were selected in Qinghai university affiliated hospital from March 2015 to October 2017. Clinical factors included age, sex, nation, TNM stage, tissue differentiation, tumor size and lymph node metastasis. HIF-2α were detected by immunohistochemical method and real-time quantitative fluorescence PCR. The colorectal cancer patients' data was analyzed by multivariate COX proportional risk regression model. Results The HIF-2α immunohistochemistry scores in nation and sex were no statistical significance (Z=-1.013, P=0.311; Z=1.300, P=0.193). The HIF-2α immunohistochemistry scores in age, tumor size and lymph node metastasis were statistical significance (Z=-8.726, P=0.001; Z=6.574, P=0.001; Z=5.853, P=0.001). The HIF-2α immunohistochemical score in Stage Ⅲ rised significantly than Stage Ⅰ and Stage Ⅱ (χ2=67.036, P=0.001). The HIF-2α immunohistochemical scores in the poorly differentiated group were increased significantly than the well differentiated group (χ2=51.595, P=0.001). The expression of HIF-2α RNA was similar to the immunohistochemistry result. Multivariate COX proportional risk regression model analysis showed that TNM stage was an independent prognostic risk factors in CRC patients (χ2=12.555, P=0.002). Survival analysis of patients with different TNM staging showed different survival rates (χ2=13.265, P=0.001). The stage Ⅲ compared with stage Ⅰ, stage Ⅱ were statistical significance (χ2=6.369, P=0.012; χ2=9.115, P=9.115). Conclusions Clinical TNM stage seems to be an important prognostic factor for the CRC patients. Therefore, early diagnosis of CRC should improve the postoperative survival. Key words: Colorectal cancer; HIF-2α; Prognosis