Abstract
IntroductionGastroesophageal reflux disease is a common disorder of the digestive tract. Esophageal mucosa exposure to gastric acid can lead to mucosal damage such as esophagitis.ObjectiveThe aim of this study was to determine the relationship between Helicobacter pylori infection in the stomach and reflux esophagitis in patients referring to the endoscopy units of hospitals in Khorramabad between 2014 and 2018.Materials and MethodsIn this cross-sectional study, all patients who referred for endoscopy to the Endoscopy Units of Shohadaye Ashayer and Shahid Rahimi Hospitals of Khorramabad during 2014-2018 were studied. H. pylori infection was diagnosed based on pathological specimens. All patientschr('39') information including age, sex, presence of esophagitis (its grade), and H. pylori infection were recorded in the questionnaires and their relationship with esophagitis and its grade as well as H. pylori infection was statistically analyzed. Tables and charts were used to describe the data. t-test and Chi-squared test were used to investigate the relationship between variables.ResultsThe frequency of esophagitis in our patients was 52.8%, with the highest frequency obtained for grade B esophagitis (48%). In this study, the prevalence of H. pylori infection was 57.5%. This rate was 55.4% in patients with esophagitis, with a statistically significant difference to the group without esophagitis (P=0.0009). There was a significant relationship between grade A esophagitis and H. pylori infection (P=0.0002).ConclusionThis study suggests a significant relationship between H. pylori infection and esophagitis in affected patients.
Highlights
Relationship between esophagitis and Helicobacter pylori complications is low [9]
Considering the high prevalence of esophagitis and H. pylori in endoscopic patients and the importance of H. pylori infection treatment and eradication, this study was conducted to investigate the relationship between H. pylori infection in the stomach and reflux esophagitis in patients referring to the Endoscopy Units of Shohadaye Ashayer and Shahid Rahimi Hospitals of Khorramabad during 2014-2018
The study of Chung et al (20042007) in Korea showed that in patients undergoing upper endoscopy, the group with erosive esophagitis had a higher prevalence of H. pylori infection than the control group, and the prevalence of the infection was inversely correlated with esophagitis at different degrees
Summary
Relationship between esophagitis and Helicobacter pylori complications is low [9]. The results of some studies indicate that eradication of Helicobacter pylori may cause esophagitis reflux and exacerbate the symptoms of esophagitis [15]. Studies have shown a low prevalence of Helicobacter Pylori in patients with GERD or esophagitis, but the sample size was low in these studies (16). Considering the high prevalence of esophagitis and H. pylori in endoscopic patients and the importance of H. pylori infection treatment and eradication, this study was conducted to investigate the relationship between H. pylori infection in the stomach and reflux esophagitis in patients referring to the Endoscopy Units of Shohadaye Ashayer and Shahid Rahimi Hospitals of Khorramabad during 2014-2018
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