Abstract
ABSTRACT The relationship between specific types of germinal cells in testicular biopsy specimens and serum FSH levels has been investigated in 49 men with infertility. Testicular biopsies were analysed quantitatively by counting the germinal cells present in cross-sections of 25 different seminiferous tubules. These quantitative histological studies demonstrated that a significant correlation exists between serum FSH levels and the mean number of spermatogonia, primary spermatocytes, early and late spermatids per tubule when each group is taken singly. No correlation was evident between the serum FSH level and the mean number of Sertoli cells. The results indicate that the most significant correlation obtained was between the mean number of spermatogonia and serum FSH levels and suggests that correlations obtained between the more mature germinal cells and FSH levels may result from the former relationship.
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