Abstract
ObjectiveTo evaluate the relationship between gastric cancer (GC) and precancerous lesions and bile reflux.MethodsMedical records of 30 465 participants who underwent gastroscopy between January and December 2018 in our center were reviewed. Their age, sex, time of endoscopy, endoscopic/histologic diagnosis and grade of bile reflux were recorded. The participants were further divided into the chronic gastritis group (n = 27 807), a precancerous lesion group (n = 1943) and a GC group (n = 715). The χ2 tests and hierarchical analyses were performed.ResultsPatients aged 18‐27 years had a higher bile reflux rate than those aged 28‐37 and 68‐75 years (P < 0.001), while it did not differ between patients aged <50 years and those over 50 years (P = 0.639). It was lower in men than in women (P < 0.001). The bile reflux rate did not differ in terms of months, seasons and half of the year (all P > 0.05), but differed between morning and afternoon when they underwent the endoscopy (P = 0.000). There was an interrelationship between the severity of gastric mucosal disease and bile reflux grade (r = 0.171). After excluding the effects of sex, age and time of endoscopy on bile reflux, bile reflux rate in chronic gastritis and precancerous lesions was lower than in gastric cancer (P < 0.01).ConclusionsBile reflux may be a risk factor for gastric cancer and precancerous lesions. A high grade of bile reflux may be associated with the progression of gastric mucosal diseases.
Highlights
As the fifth most common malignant tumor worldwide, more than one million new cases of gastric cancer (GC) were estimated to be diagnosed in 2018; while the cancer-related mortality rate of GC is the third highest.[1]
We included adult patients aged between 18 and 75 years who were diagnosed as endoscopically or histologically confirmed chronic gastritis and/or intestinal metaplasia, mild to moderate atypical hyperplasia, or those having a definite diagnosis of GC
For non-GC patients who had obvious lesions other than intestinal metaplasia under endoscopy, such as localized erosion, patches of changed color and superficial protrusions, one to five biopsy specimens were taken as determined by the endoscopic physician; while no biopsy was performed in when no obvious lesions under endoscopy
Summary
To evaluate the relationship between gastric cancer (GC) and precancerous lesions and bile reflux. Methods: Medical records of 30 465 participants who underwent gastroscopy between January and December 2018 in our center were reviewed Their age, sex, time of endoscopy, endoscopic/histologic diagnosis and grade of bile reflux were recorded. Results: Patients aged 18-27 years had a higher bile reflux rate than those aged 28-37 and 68-75 years (P < 0.001), while it did not differ between patients aged
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