Abstract
Coronary Artery Disease (CAD) is one of the leading causes of death and a significant public health concern. Approaches to early diagnosis of individuals at risk for CAD have always been a subject of research. The Frank sign is one of these approaches. The Frank sign is an independent risk factor for CAD and can be used, especially in the diagnostic process, to identify individuals at risk in the early stages. However, more studies and more extensive series should further support this finding.
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