The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Cenk Soysal,İsmail Biyik,Hatice Sari,Onur Ince,Yasemin Tasci,Özlem Erten,Nadi Keskin

doi:10.21613/gorm.2021.1215

Abstract

OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

Highlights

Birth weight is an important parameter for mortality and morbidity in the neonatal period
We aimed to investigate whether the biochemical parameters used in first-trimester aneuploidy screening are related to birth weight and to determine the prediction accuracy of these parameters for small for gestational age (SGA) and large for gestational age (LGA) in newborns
This study aimed to investigate the relationship between birth weight and serum pregnancy-associated plasma proteinA (PAPP-A), β-hCG, and ultrasonographic nuchal translucency (NT) measurements among the first-trimester aneuploidy markers

Summary

Introduction

Birth weight is an important parameter for mortality and morbidity in the neonatal period. Birth weight is affected by various factors, the main reasons are gestational age, genetic factors, BMI (Body Mass Index), maternal systemic. Gynecol Obstet Reprod Med. 2021;Article in Press diseases, ethnic origin, maternal age, parity, and smoking habit [1,2,3]. The rates of neonatal complications such as stillbirth, necrotizing enterocolitis, and respiratory distress syndrome increase in infants with small for gestational age (SGA) (defined as less than 10th percentile birth weight) [4,5]. Large for gestational age (LGA) neonates (defined as over 90 percent of birth weight) have increased obstetric complications such as shoulder dystocia or other birth injuries and cesarean delivery, as well as a higher chance of complications such as obesity, cardiovascular disease, and metabolic imbalance in adulthood [6,7]

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