Abstract

Objective The main goal of our study was to assess relationships between first trimester 25-hydroxyvitamin D3 levels and infant birthweight and length at birth. Materials and Methods We conducted a study over our medical records of 154 live-term births at Acibadem Atakent Hospital, Istanbul, Turkey. Subjects were classified into five independent groups. Results We retrospectively reviewed a total of 154 live birth records. They took vitamin D3 supplement 1000 U/day. We classified the serum vitamin D levels into 5 groups by concentration. Group 1 comprised serum vitamin D levels <10 ng/ml (n = 41); group 2 comprised serum Vitamin D levels between >10–16 ng/ml (n = 33); group 3 comprised serum vitamin D levels >16–20 ng/ml (n = 26); group 4 vitamin D level between >20–30 ng/ml (n = 33) and group 5 comprised vitamin D levels >30 ng/ml. The femurs of infants were found to be longer between the groups, although the differences were not significant (p=0.054). There was also a statistically significant difference in the neonatal birth weight (p=0.048). Conclusion We observed associations between low and high maternal 25-hydroxyvitamin D3 levels and fetal growth at birth weight but no difference in birth length. We conclude that we always need to conduct further research to be able to predict the effects of vitamin D deficiency.

Highlights

  • Vitamin D deficiency is a global health problem

  • Group 1 was comprised of serum vitamin D levels 10– 16 ng/ml (n 33); group 3 was comprised of serum vitamin D levels >16–20 ng/ml (n 26); group 4 vitamin D level between >20–30 ng/ml (n: 33) and group 5 was comprised of vitamin D levels >30 ng/ml

  • 47% of the deliveries were vaginal and 53% were by cesarean section (C-section). e median birthweight was 3287.5 g, and the median femur-length at birth 51 cm. e serum vitamin D levels were classified into 5 groups by concentration

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Summary

Introduction

Vitamin D deficiency is a global health problem. Low vitamin D levels can be coexistent with preeclampsia, intrauterine growth restriction, small-for-gestational age sizes, skeletal problems, diabetes, and asthma. E effects of vitamin D levels on pregnancy bone mineralization and fetal growth are known. Controversies remain about the relationship between pregnancy serum 25-hydroxyvitamin D3 levels and neonatal weight. Two observational studies have reported a positive association [1]. E risk of neonatal vitamin D deficiency and the risk of lower birth weight are both increased by a maternal vitamin D deficiency [2]. Several studies have reported positive effects on birth length and birth weight. Ere is growing evidence that links vitamin D deficiency to immune system dysfunction, abnormal angiogenesis, and preeclampsia [3] Several studies have reported positive effects on birth length and birth weight. ere is growing evidence that links vitamin D deficiency to immune system dysfunction, abnormal angiogenesis, and preeclampsia [3]

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