Abstract
To study the relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma (HCC). The expression of FHIT and WWOX were determined by immunohistochemistry in 142 patients with HCC. Absent or reduced FHIT and WWOX expression was observed in 68.3% and 77.5% of HCCs, respectively. The expression of FHIT was significantly correlated with that of WWOX (P < 0.01), and progressive loss of FHIT and WWOX expression were observed as tumor differentiation decreased and tumor grade increased (P < 0.05). Absent/reduced FHIT and WWOX expression was associated with tumor invasion and metastasis (P < 0.05). In addition, the expression of FHIT and WWOX in HCC with recrudesce were lower than that in those without recrudesce (P < 0.05). Absent/reduced FHIT and WWOX expression is associated with poor prognosis.
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