The relationship between estimated glomerular filtration rate and urine m/creatinine ratio and parathyroid hormone in elderly Koreans.

Abstract

This study aimed to assess the relationship between estimated glomerular filtration rate (eGFR), urine microalbumin/creatinine ratio (uACR), and parathyroid hormone (PTH) levels in elderly Korean men and women. Data were analyzed from 2880 adults (1262 men and 1618 women) aged ≥ 50years from the Fifth Korean National Health and Nutrition Examination Survey V-2 (KNHANES V-2). In men, after adjusting for related variables, the odds ratios (ORs) of the high PTH levels (PTH > 78.0ng/L) were significantly higher in the decreased eGFR group [eGFR < 60ml/min/1.73m2; 1.353 (95% confidence interval [CI], 0.989-1.851)], elevated uACR group [uACR ≥ 30mg/g; 1.804 (95% CI, 1.004-3.239)], and decreased eGFR plus elevated uACR group [eGFR < 60ml/min/1.73m2 and uACR ≥ 30mg/g; 2.158 (95% CI, 1.208-3.858)] relative to the normal group (eGFR ≥ 60ml/min/1.73m2 and uACR < 30mg/g). In women, after adjusting for related variables, the ORs of the high PTH levels were significantly higher in the decreased eGFR group [1.585 (95% CI, 0.911-2.760)], elevated uACR group [1.645 (95% CI, 1.127-2.400)], and decreased eGFR plus elevated uACR group [2.934 (95% CI, 1.267-6.795)] relative to the normal group. In conclusion, PTH was positively associated with an increase in uACR in elderly Korean men and women but was not associated with a decrease in eGFR. In addition, PTH increased greatly when both a decrease in eGFR and increase in uACR appeared simultaneously.