Abstract
In this study, it was aimed to investigate the relationship between the epicardial adipose tissue thickness (EATT) and serum IL-17A level insulin resistance in metabolic syndrome patients. This study enrolled a total of 160 subjects, of whom 80 were consecutive patients who applied to our outpatient clinic and were diagnosed with metabolic syndrome, and the other 80 were consecutive patients who were part of the control group with similar age and demographics in whom the metabolic syndrome was excluded. The metabolic syndrome diagnosis was made according to International Diabetes Federation (IDF)-2005 criteria. EATT was measured with transthoracic echocardiography (TTE) in the subjects. IL-17A serum levels were determined using the ELISA method. Fasting blood glucose, HDL, triglyceride, and fasting insulin levels were significantly higher in the metabolic syndrome group compared to the control group. In addition, the metabolic syndrome group had significantly higher high-sensitivity C-reactive protein (hs-CRP) and Homeostatic Model Assessment Insulin Resistance (HOMA-IR) levels than the control group. Similarly, serum IL-17A levels were significantly elevated in the metabolic syndrome group compared to the control group statistically (p < 0.001). As well, EATT was higher in the metabolic syndrome than the control group. Conclusion: By virtue of their proinflammatory properties, EATT and IL-17 may play an important role in the pathogenesis of the metabolic syndrome.
Highlights
Metabolic syndrome is defined as a constellation of risk factors, mainly visceral obesity accompanied by hypertension, dyslipidemia, and impaired fasting glucose
The comparison of the laboratory’s parameters and echocardiographic parameters revealed that fasting plasma glucose, HDL, Triglyceride, GGT, AST, ALT and fasting insulin levels were significantly greater in the metabolic syndrome group
As for insulin resistance, the comparison of Homeostatic Model Assessment Insulin Resistance (HOMA-IR) values between the two groups showed that the metabolic syndrome group had a significantly greater HOMA-IR level compared to the control group
Summary
Metabolic syndrome is defined as a constellation of risk factors, mainly visceral obesity accompanied by hypertension, dyslipidemia, and impaired fasting glucose. The importance of metabolic syndrome stems from an excess risk of type 2 diabetes mellitus (DM) and coronary artery disease [2]. It has transformed into an important public health problem. Visceral obesity and associated insulin resistance play an important role for the development of metabolic syndrome. Low-grade inflammation plays an important role for the pathogenesis of the metabolic syndrome and coronary artery disease. In patients with metabolic syndrome, inflammation induces insulin resistance and atherosclerosis through a variety of mechanisms [3]
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