Abstract
Sulphonylureas improve glucose tolerance by stimulating insulin secretion. Whether improved glucose tolerance results from enhanced early insulin release or greater total insulin secretion is not clear. Therefore insulin and C-peptide responses to oral glucose were measured in healthy subjects with and without a single dose of oral and intravenous glipizide. The intravenous glipizide administration caused a marked early insulin response, whereas oral glipizide administration resulted in greater total and peak insulin concentration. Oral glipizide did not reduce plasma glucose until 45 min of the glucose load. In contrast, enhancement of the early insulin response with intravenous glipizide almost completely prevented postprandial glucose rise. In conclusion, early insulin release is a major factor determining oral glucose tolerance in healthy subjects.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Scandinavian journal of clinical and laboratory investigation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
