The relationship between diet pattern of IBS patients and H2/CH4 production (637.18)

Abstract

The relationship between diet pattern of IBS patients and H2/CH4 production Background: bacterial overgrowth is highly prevalent among IBS‐patients. Intestinal overgrouth of bacteria, produced H2 or CH4 was found to correlate with the spectrum of IBS symptoms. However, the influence of diet pattern in IBS patients to H2/CH4 production was not widely assessed.Aim: to assess the relationship between diet pattern of IBS patients and H2/CH4 production.Methods: Eighty three IBS patients according to Rome III criteria (34 IBS‐D/49 IBS‐C) were evaluated by lactulose breath test (LBT, Gastrocheck, Bedfont Scientific Ltd, UK). LBT was performed using 10 g of lactulose mixed in 150 mL of water, and breath samples collected every 15 min for a 180‐min period. “H2‐producers” and “CH4‐producers” were defined as with the presence of H2 peak >20 ppm more than the basal sample and mean CH4 excretion of 12 ppm, respectively. Dietary pattern of patients was assessed using food frequency questionnaire.Among 83 IBS patients tested by LBT, 10 patients prodused no excess of H2/CH4, 24 were CH4‐producers, 40 were H2‐producers and 9 have excess production both gases. CH4‐producers demonstrated a sighnificantly higher protein intake (112.3±6.4 g/d, p < 0.05) and higher fiber intake (24,8±6,1g/d, p=0.05) then H2‐producers (80.1±9.6g/d and 15,5±4,4g/d, respectively).Table 1. Nutritional data of IBS groups. Nutrients\Groups No any,n=10 Ð2 ‐ producersn=40 CH4 ‐ producersn = 24 Ð2+CH4‐ producers n = 9 Protein, g 91,7±27,2 80,1±9,6* 112,3±6,4* 101,2±14,4 Fat, g 98,2±43,3 93,7±33,4 73,3±13,2 114,7±46,7 MDS,g 81,3±45,8 111,0±71,8 108,5±84,3 102,3±69,7 Carbohydrates, g 241,1±132,0 252,9±121,3 214,1±142,7 234,3127,7± Fiber,g 6,9±5,6 15,5±4,4* 24,8±6,1* 13,0±2,5 Energy, kkal/d 2222,0±369,0 2231,9±721,5 1973,0±664,0 2375,0±997,0 * ‐ р = 0,05 Excessive CH4 production in IBS patients is associated with higher protein and fiber intake. Therefore, treatment options of methanogenic bacteria overgrowth should include dietary modifications for correction protein intake that may decrease SIBO symptoms in IBS patients.