The Relationship Between Cytomegalovirus Antibody (Anti-CMV) Test Positivity and Some Hematological and Biochemical Parameters in the Pediatric Age Group

Abstract

Objective: Cases of Cytomegalovirus (CMV) infection are encountered in the early stages of life in developing countries. The aim of this study is to specify the seroprevalence of CMV-IgM and IgG in pediatric patients and to indicate its relationship with certain hematological, serological, and biochemical parameters. Material and Methods: Serological test results of CMV-IgM and CMV-IgG in children aged 0-14 with CMV as a causative agent were analyzed retrospectively in the blood samples sent to the Microbiology Laboratory of Dursun Odabas Medical Center of Van Yuzuncu Yil University between 2013 and 2015. The relationship with hematological and biochemical parameters was investigated in the cases with positive CMV-IgM results. Results: CMV-IgM and IgG tests were studied in 1.385 children. It was determined that 58% of these children were boys and 42% were girls. A total of 112 (8.2%) of the 1.363 patients who were tested for CMV-IgM were found to be positive. The decrease in IgM with age was found to be statistically significant (p<0.01). It was determined that 707 (95.3%) of 742 patients who were tested for CMV-IgG were positive. Similarly, the increase in IgG parallel to age was found to be statistically significant (p<0.05). The correlation between positivity values of CMV-IgM-positive patients and patients’ hematological, serological, and biochemical parameters were calculated separately. It was noted that the significant value in the correlation was C-reactive protein with 0.49 (p<0.01). Conclusion: CMV-IgG seroprevalence was found to be higher compared with studies conducted in developed countries. Accordingly, we think that increased C-reactive protein levels will be useful in the diagnosis of CMV.