Abstract
Purpose: Not all obese people have hyperglycemia. We wondered about the healing progress in obese people without hyperglycemia. The purpose of this study is to observe the cutaneous wound healing process. Methods: Three-week-old male mice were fed high-fat diets (containing 60% fat) in the diet group, and commercial diets in the control group, ad libitum for 15 weeks. Circle-full-thickness cutaneous wounds were made on the dorsal skin of mice. From day 0 to day 15 after wounding, we analyzed wound healing process. We measured the blood concentration of leptin, and observed the distribution of leptin-positive cells in each wound. Results: Mean body weight, the areas of subcutaneous fat and visceral fat, and the weight of epididymal fat in the diet group were significantly greater than those in the control group at 15 weeks after feeding. The diet group did not feed on the diet after wounding; their body weight decreased remarkably to the level of the control group. The ratio of wound area, re-epithelialization, and collagen fibers did not differ between the diet and control groups on each day. The blood concentration of leptin in the diet group was significantly greater than that in the control group before wounding and until day 6 after wounding (day 0, 10 hour and day 1: p < 0.01, day 6: p < 0.05). Conclusion: The results show that the wound healing process is similar between obese and non-obese mice, and that the decrease in the leptin level in the obese mouse to that in the non-obese mouse may depend on the decrease of body weight of obese mouse.
Highlights
Obesity is excessive fat accumulation [1] [2]
The Japan Society for the Study of Obesity (JASSO) decided to define body mass index (BMI) ≥ 25 as obesity [2] and Kanazawa M et al proposed that BMI ≥ 25 is the appropriate criteria for obesity in Japan and the Asia-Oceania region [1]
We focused on leptin to search for the reason
Summary
Obesity is excessive fat accumulation [1] [2]. The World Health Organization (WHO) has defined obesity as a body mass index (BMI) equal to or above 30 [3]. The Japan Society for the Study of Obesity (JASSO) decided to define BMI ≥ 25 as obesity [2] and Kanazawa M et al proposed that BMI ≥ 25 is the appropriate criteria for obesity in Japan and the Asia-Oceania region [1]. Obesity is a major cause of type 2 diabetes [4] which is clinically shown hyperglycemia [5] [6]. The proportion of hyperglycemic men with BMI 26 - 27.9, 28 - 29.9, or ≥30 was 11.3%, 15.0%, or 15.4%, respectively. The proportion of hyperglycemic women was 11.8%, 16.4%, or 19.4%, respectively, for each classification of BMI. According to a previous population-based cross-sectional study [8] using data from the 2000-2011 national Medical Expenditures Panel Surveys, the proportion of non-diabetic respondents with BMI ≥ 30 was 25.2% of 109,569
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