Abstract
Background: Herein, we validate the psychometric properties of the Chinese version of the THINC-integrated tool (THINC-it) as a screening tool for cognitive deficits in patients with major depressive disorder. The primary aim of this study is to determine whether cognitive deficits as detected by the THINC-it tool in adults with major depressive disorder (MDD) are associated with workplace productivity and/or psychosocial function.Methods: Subjects aged 18–65 (n = 91) with MDD were evaluated and compared to age-, sex- and education- matched healthy controls (n = 95). Symptoms of cognitive dysfunction, workplace productivity, and psychosocial function were measured using the THINC-it tool, Hamilton Depression Scale (HAMD), Sheehan Disability Scale (SDS), The Work Productivity and Activity Impairment questionnaire- Specific Health Problem (WPAI-SHP).Results: There were significant differences in THINC-it scores (p < 0.01), the average of HAMD total score (p < 0.01) and all aspects of SDS (p < 0.01) between two groups. There were significant differences in the four aspects of WPAI between the two groups in the employed status (p <0.01). THINC-it subjective cognition and SDS total score, SDS work/school, SDS social, SDS family showed significantly correlation (r ranging from 0.255 to 0.386, p <0.01). SDS and THINC-it Objective cognition, THINC-it comprehensive cognition were no correlation between two groups. HAMD total score and SDS total score, SDS social, SDS family showed significantly correlation (r ranging
Highlights
Major depressive disorder (MDD) is common, debilitating and associated with significant human capital costs [1, 2]
The education level and IQ of patients with MDD were lower than healthy controls (HC); there was no difference between the two groups in terms of age, gender, and the employment status
Compared with HC, the average Hamilton Depression Scale (HAMD) total score and THINCit scores were significantly higher in the MDD group (p < 0.01)
Summary
Major depressive disorder (MDD) is common, debilitating and associated with significant human capital costs [1, 2]. The majority of patients with MDD do not regain premorbid levels of psychosocial functioning despite the resolution of core depressive symptoms. Evidence indicates that cognitive functions play a critical role in mediating functional outcomes in MDD [4, 5]. Evidence indicates that Perceived Deficits Questionnaire (PDQ) scores correlate with patient reported outcomes [6]. Only the subjective five-item Perception Deficits Questionnaire (PDQ-5-D) was used to assess the cognitive dysfunction [7,8,9]. The primary aim of this study is to determine whether cognitive deficits as detected by the THINC-it tool in adults with major depressive disorder (MDD) are associated with workplace productivity and/or psychosocial function
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