Abstract
Background: Coffee is known to have a protective effect on liver enzymes. There are a limited number of Asian studies on this subject. We investigated the relationship between coffee and liver function tests in Korean men on a large scale. Methods: Study participants were consecutive men who had a regular health checkup in a university hospital in Korea. Information on coffee intake, alcohol drinking, and smoking was collected through self-administered questionnaires. Results: A total of 3,844 men were enrolled in this study. Coffee drinking was positively associated with smoking and alcohol drinking. Coffee drinking was inversely associated with aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) concentrations (r=−1.33, p=0.008 and r=−6.35, p=0.007, respectively). Also, increasing levels of coffee consumption was inversely associated with AST and GGT in a multivariate model (p<0.001 and p<0.001, respectively). The relationship between coffee drinking status and alanine aminotransferase...
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