The relationship between CA125 status and P53, WT1 and clinical features in epithelial ovarian cancer

Abstract

To investigate the relationship between ER status, P53, WT1, CA125 and clinical characteristics of epithelial ovarian cancer, and the differential diagnosis value of low grade and high grade serous ovarian cancer. 34 patients with epithelial ovarian cancer admitted to our hospital were selected as the research object, and divided into low grade group and high grade group according to the histological grade of ovarian cancer. The immunohistochemical expressions of ER, P53 and WT1 in the two groups were compared and analyzed, and their correlation and clinicopathological parameters were analyzed. The total positive rates of P53 and WT1 in ovarian cancer were 55.88% and 41.18%. The proportion of P53 positive expression in high-grade group was significantly higher than that in low-grade group, while the WT1 positive rate was lower than that in low-grade group, the difference was statistically significant (P < 0.05). The WT1 (+) &P53 (+) group had a higher level of CA125 than the non-expression group, and the difference was statistically significant (P < 0.05). WT1 protein was significantly correlated with pathological stage, degree of differentiation, pathological type and lymph node metastasis of epithelial ovarian cancer (P < 0.05),which could be used as an important prognostic factor for patients. The expression level of P53 is higher in high-grade serous ovarian cancer, while the expression level of WT1 is lower. The use of P53 and WT1 can diagnose high-grade serous ovarian cancer, and WT1 has higher diagnostic value for low-grade serous ovarian cancer. The CA125 status was significantly correlated with the expression of P53 and WT1.