The relationship between antihypertensive therapy and renal function in 152 hypertensives

Abstract

Objective: To observe the effects of antihypertensive therapy on serum creatinine (CRE) and estimated glomerular filtration rate (eGFR) in hypertensive patients. Methods: Totally 152 hypertensives were randomly divided into four groups (group A: amlodipine+telmisartan, B: amlodipine+amiloride, C: amlodipine+telmisartan+simvastatin, D: amlodipine+amiloride+simvastatin). They were followed for 2 years. Results: After 3 months of treatment, means of SBP and DBP declined within normal range for four groups (P<0.001). After 1 year of treatment, mean of CRE was significantly decreased by 13.51 umol/L (t=9.796, P<0.001); eGFR was significantly increased by 27.4 mL/min/1.73m2 (t=−7.178, P<0.001). After 2 years of treatment, means of SBP and DBP decreased by 28.16 mmHg and 10.07 mmHg, respectively (t=24.731, P<0.001); CRE decreased by 19.17 umol/L (t=13.69, P<0.001); eGFR was increased by 43.23 umol/L (t=−11.048, P<0.001). Means of CRE and eGFR among the four groups did not have differences (P>0.05). Conclusions: The effects of the combination of two antihypertensive drugs in hypertensives are significant, it can not only decrease BP and CRE, but also increase GFR. Decreasing BP can protect the kidney and improve the renal function. Different antihypertensive drugs had no significant difference in benefiting the renal function.