Abstract
Abstract Acylation of 14-hydroxycodeinone with long chain unbranched fatty acids produced compounds of varying analgesic potency, maximal activity being in 14-n-heptoyl-oxycodeinone. In 14-phenylalkyloxy derivatives maximal analgesic potency was found in 14-cinnamoyloxycodeinone. All codeinone derivatives studied had approximately one-third the duration of morphine in mice. Intravenous and subcutaneous toxicities in mice were generally similar in compounds causing death by convulsions, but differed widely in those causing death by respiratory depression.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
