The relationship between adiponectin gene polymorphism and cerebral white matter lesions

Abstract

Objective To investigate the association between adiponectin gene single nucleotide polymorphism(SNP) and white matter lesions(WML) in middle aged and elderly subjects. Methods From June 2012 to January 2013, the clinical data and blood indicators of 811 patients in the Neurology Department of Daping Hospital of Third Military Medical University were conducted a cross sectional study. The diagnosis of WML was made according to the MRI results referred to Fazekas standards. Four hundred and ninteen WML patients were included into study group and 392 patients without WML were included into control group. Genotyping was performed using ligase chain reaction. Multivariate logistic regression analyses were performed to examine the association of WML with SNP. Results The patients in study group were older, and showed significantly higher proportion of coronary heart disease (CHD), prior stroke, hypertension, and diabetes mellitus, and higher levels of fasting blood glucose whereas lower levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-Ⅰ compared with those in control group (all P values<0.05). The distribution of AA, AT, TT genotype and A, T allele frequency of rs7649121 was different between the two groups significantly. After adjustment for age, sex, prior stroke, CHD, hypertension, diabetes and HDL-C levels, AT and TT were associated with higher risk of WML independently. In dominant model, AT/TT genotype was 1.73 times more likely to have WML than AA genotype. Conclusions Among the middle aged and elderly subjects, the present study firstly find that rs7649121 in adiponectin gene may be associated with WML, and T allele is probably a susceptible allele of WML. Key words: Cerebral white matter lesions; Adiponectin; Gene polymorphism; Middle aged; Aged