Abstract
other animal retroviruses, including long terminal repeat, group-specific polymerase, envelope, and transactivation genes. Human retroviruses discovered to date have been associated with lymphoproliferative or cytopathic disease states. Human immunodeficiency virus (HIV) shares genomic sequence, structural features, replicative mechanisms, and cytopathic features with other animal lentiviruses. Lentiviruses, such as HIV, share the common biological features of inducing fusion and death of infected host cells. Restricted transcription of viral gene products (in concert with host factors) and antigenic variation (primarily in the envelope gene) allow these viruses
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