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Abstract
A NEW IMPETUS was given to the study of the cytology and physiology of the thyroid when it was observed that certain compounds, when administered to animals, produce marked enlargement of their thyroid glands. Kennedy and Purves (1941) had shown that when animals are fed a Brassica seed diet, extreme hyperplasia of the thyroid glands ensues. Astwood, Sullivan, Bissell, and Tyslowitz (1943) and MacKenzie and MacKenzie (1943) showed that certain sulfonamides and thiourea-like drugs not only induce enlargement of the thyroid but lower the basal metabolic rates of animals as well. Later Griesbach and Purves (1943), Astwood and Bissell (1944), Franklin, Lerner and Chaikoff (1944), and Rawson, Tannheimer and Peacock (1944) showed clearly that these drugs interfere with the metabolism of iodine and that the thyroids of animals receiving them are unable to take up iodine or synthesize thyroxine. Supplemental iodine, even in large amounts, proved ineffective in preventing the changes in the thyroid induced by thes...
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