Abstract
At the meeting of the American Physiological Society, April 11, 1933, we made a report on this subject which may be summarized as follows:(1) Spontaneous glycosuria had not been observed in a hypophyseetomizedpancreatectomized dog but glycosuria could be produced at will by injection of anterior lobe extracts. (2) Glycosuria had been produced in normal dogs by injection of suitable anterior pituitary extracts. (3) These same extracts did not produce glycosuria in a thyroidectomized dog. At this time we wish to report the details and extension of these experiments. The experimental evidence for an interrelationship between the anterior hypophysis and carbohydrate metabolism will be briefly considered under three divisions, (1) hypophysectomy, (2) hypophysectomy and pancreatectomy, and (3) injection of anterior lobe extracts. The most striking changes in carbohydrate metabolism after hypophysectomy are (1) sensitivity to insulin (Houssay and Magenda, 1924; Geiling. et al., 1927) and (2) hypoglycemic convuls...
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