Abstract
ALTHOUGH the evidence is clear that the endocrine system regulates certain phases of blood formation (reviewed by Gordon and Charipper, 1947), its significance in blood destruction processes still remains to be elucidated. Of the organs examined, the spleen has been the subject of most investigation and in this connection, Gordon and Kleinberg (1937) and Gordon, Kleinberg and Ponder (1937) have reported a decrease in red cell fragility following splenectomy both under in vitro and in vivo conditions. That the adrenal may also be implicated in blood destruction mechanisms has been indicated in reports by Reid (1932) and more recently by Gordon and Piliero (1950) who have detected an increased resistance of the red cell of the adrenalectomized animal towards hypotonic saline. It was felt that a more extensive investigation of the relation of the adrenal to red blood cell fragility might provide a clue as to the general significance of the endocrine system in blood destruction processes.
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