The Relation of Retinol-Binding Protein 4 ( RBP4 ) with Insulin Resistance in Hemodialysis Patients

Abstract

Background: Insulin resistance (IR) is one of the important causes of abnormal glucose homeostasis in CKD even in the absence of overt diabetes mellitus. Retinol-binding protein 4 (RBP4) is a lipocalin superfamily molecule that is synthesized primarily by hepatocytes and adipocytes. CKD may contribute to the increased survival and retention of RBP4 in the circulation. RBP has recently been proposed as a novel adipokine involved in the metabolism of glucose. Objective: To evaluate Retinol Binding Protein 4 in stage 5 Chronic kidney disease patients on regular hemodialysis and its contribution to insulin resistance in those patients. Patients &Methods: The patients divided into 2 groups: Group I: Patients group consist of 50 ESRD patients on regular hemodialysis; they were 20 females (40.0%) and 30 males (60.0%) with age ranged from 19 years to 52 years and with mean±SD (38.08±7.1 years). Group II: Control group consists of 50 normal subjects; 26 females (52%) and 24 males (48%) with age ranged from 21 years to 51 years and with mean±SD (35.38±8.77 years). Results: comparison between group I and group II show that there was highly significant increase in RBP4 (p 0.000) while no statistically significant difference found between the two studied groups regarding HOMA (p 0.260). Conclusion:no correlation betweenRBP4 and HOMA in hemodialysis patients.