The relation of postprandial plasma glucose and serum endostatin to the urinary albumin excretion of residents with prediabetes: results from the Kyushu and Okinawa Population Study (KOPS).

Abstract

Previous clinical studies have shown that the circulating level of endostatin is related to kidney injury. We hypothesized that the impact of HbA1c, fasting, and postprandial plasma glucose on urinary albumin excretion would be related to the serum endostatin level. A cross-sectional, community-based population study of 1057 Japanese residents was conducted. Of these subjects, 162 with a fasting plasma glucose value between 5.5 and 6.9mmol/L and an HbA1c level of <6.5% received an oral glucose tolerance test, had serum endostatin measured, and had the urinary albumin/creatinine ratio (UACR) calculated. In multivariate analysis, 2-h postprandial plasma glucose (β=0.26, P<0.01) was significantly associated with log-transformed UACR, independently of fasting plasma glucose (β=0.14, P=0.28) and HbA1c (β=-0.08, P=0.57). When divided by the median value of endostatin (82.2ng/mL), 2-h postprandial plasma glucose (β=0.38, P=0.01) remained significantly associated with the log-transformed UACR of the participants below the median, while the fasting plasma glucose (β=0.34, P=0.046) was independently associated with the log-transformed UACR of participants above the median. Postprandial plasma glucose was independently associated with the urinary albumin excretion of the residents with prediabetes. Moreover, this relationship was limited to residents with a serum endostatin level below the median.