Abstract
Summary and Conclusions Alcoholic tissue-extracts prepared according to a uniform procedure are identical in antigenic activity when standardized by determination of the optimal ratio, cholesterol:extract. The practical application of these methods offers the means for maintaining a constant maximal degree of antigen-sensitivity in complement-fixation tests for syphilis. With tissue-extracts prepared by the method to which reference is made, optimal cholesterol-concentration is, within detectable limits, related by direct proportion to the saline dilution of antigen that elicits a given maximal serum-reaction. Thus, it appears that, under constant conditions, a quantitative relation exists between optimal cholesterol-concentration, the essential constituents of alcoholic tissue-extract, and a given degree of serum-reaction, so that a gravimetrically determined quantity of cholesterol may be made the standard of reference in the adjustment of antigen for use in complement-fixation tests for syphilis.
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