Abstract
AbstractA time study of the incorporation of tritiated thymidine into the thymus of Fischer rats ranging from 15 days to one year of age has been made. The data obtained from both autoradiographic and histological analyses indicate that the mitotic activity in the thymus of young animals is much higher than in old animals. The medium thymocyte, by virtue of its higher relative proliferative capacity, is responsible for the greater portion of cellular production during the intense pre‐pubertal growth phase of the thymus. A decrease in proliferative capacity of medium thymocytes occurs between 60 and 90 days of age, which appears to initiate the onset of age involution of the thymus. The data further indicate that small thymocytes are cells which do not undergo division.
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