Abstract
BackgroundBlood groups are considered to have an impact on the occurrence and severity of coronavirus disease. While among Chinese and Caucasian, blood group O individuals were less and group A were more likely to have severe disease and mortality, data on South Asians aren’t available. ObjectiveThis study aimed to find out the association of disease severity with blood group among coronavirus disease 2019 (COVID-19) patients.Materials and methodologyData were collected on a predesigned questionnaire containing details of patient demographics, medical comorbidities, clinical presentation, and laboratory parameters. Multiple logistic regression was used to determine the association of the blood group with the severity of coronavirus disease.ResultAmong the study participants, blood group B has the highest distribution (39.8%), followed by O (30.0), A (21.9%), and AB (8.1%). About three-fourths (69.9%) had mild to moderate disease while 30.0% had severe disease. Age, gender, hypertension, diabetes mellitus, and hemoglobin level were all associated with disease severity among COVID-19 patients in univariate analysis on P-value for selection (<0.25). The final model showed that the odds of disease severity is 3.62 times higher among males (OR: 3.62, 95% CI: 2.15-6.08) and 2.00 times higher among diabetic patients (OR: 2.00, 95% CI: 1.10-3.01) as compared to female and non-diabetic respectively. However, there was no significant association found between blood group and disease severity.ConclusionBlood groups don’t have any role in forecasting the severity of coronavirus disease. However, the male gender and diabetics are prone to have severe disease.
Highlights
On 31st December 2019, 27 cases of pneumonia of unidentified etiology were documented in Wuhan City, Hubei province in China [1]
This study aimed to find out the association of disease severity with blood group among coronavirus disease 2019 (COVID-19) patients
The causative agent was recognized from throat swab samples conducted by the Chinese Centre for Disease Control and Prevention (CCDC) on 7th January 2020 and was later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Summary
On 31st December 2019, 27 cases of pneumonia of unidentified etiology were documented in Wuhan City, Hubei province in China [1]. The causative agent was recognized from throat swab samples conducted by the Chinese Centre for Disease Control and Prevention (CCDC) on 7th January 2020 and was later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel coronavirus SARS-CoV-2, causing the novel coronavirus disease2019 (COVID-19), is currently spreading briskly worldwide; it has been recently declared as a pandemic by WHO. Evidence shows that blood groups have an impact on the occurrence and severity of coronavirus disease. Blood groups are considered to have an impact on the occurrence and severity of coronavirus disease. While among Chinese and Caucasian, blood group O individuals were less and group A were more likely to have severe disease and mortality, data on South Asians aren’t available
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