The Relation betweenHelicobacter pyloriInfection and Acute Bacterial Diarrhea in Children

Maryam Monajemzadeh,Parin Tanzifi,Leila Kashi,Ata Abbasi,Heshmat Irani,Sahar Taba Taba Vakili

doi:10.1155/2014/191643

Abstract

Background. H. pylori infection leads to chronic gastritis in both children and adults. But recently, there are arising theories of its protective effect in diarrheal diseases. Aim. To explore the prevalence of H. pylori infection in children with bacterial diarrhea and compare it with healthy controls. Patients and Methods. Two matched groups consisted of 122 consecutive children, aged 24–72 months old, with acute bacterial diarrhea, who had Shigellosis (N = 68) and Salmonellosis (N = 54) as patients group and 204 healthy asymptomatic children as control group enrolled in this study. Results. The prevalence of H. pylori infection in healthy control children was significantly higher than in patients group, (odds ratio = 3.6, 95% CI: 1.33–9.5, P = 0.007). In our study, only 2/54 Salmonella infected patients and 3/68 of Shigellosis had evidence of H. pylori infection, while normal control children had 27/204 infected individuals. Conclusion. H. pylori infection may play a protective role against bacterial diarrhea in children. So it is important to consider all of the positive and negative aspects of H. pylori infection before its eradication.

Highlights

Helicobacter pylori (H. pylori) is one of the most important factors in the gastroduodenal diseases
The prevalence of H. pylori infection in control group was significantly higher than in acute bacterial diarrhea group (P = 0.007), in which two of fifty-four cases of Samonella infection and three of sixty-eight cases of Shigellosis were infected by H. pylori while 27 out of 204 control children were infected
The risk of positive H. pylori infection in control group was 3.6 times higher than bacterial infection group (Table 1)

Summary

Introduction

Helicobacter pylori (H. pylori) is one of the most important factors in the gastroduodenal diseases. The infection is most commonly acquired in early childhood and leads to chronic gastritis in both children and adults and is the leading cause of peptic ulcer disease in humans [1,2,3,4]. It is a challenging matter for many physicians due to lack of knowledge about its life cycle and low rate of bacterial eradication. Aim. To explore the prevalence of H. pylori infection in children with bacterial diarrhea and compare it with healthy controls. It is important to consider all of the positive and negative aspects of H. pylori infection before its eradication

Methods

Results

Conclusion