Abstract
SARS CoV-2 is a novel coronavirus which has caused many deaths in the recent pandemic. This study aimed to determine zinc, copper and magnesium status on pregnant women with COVID-19. 100 healthy (33/32/35) and 100 SARS-CoV-2 positive (34/33/33) pregnant women were included in the study according to their trimesters. Blood samples were obtained from the patients along with the initial laboratory tests for clinical outcomes upon their first admission to hospital. In the first and third trimesters serum zinc level was lower (p:0,004 and p:0,02), serum copper level was higher (p:0,006 and p:0,008), the Zn / Cu ratio decreased(p < 0.0001 and p < 0.0001) and the serum magnesium level was higher(p < 0.0001 and p < 0.0001) in the COVID-19 group.In the second trimester COVID-19 patients had lower serum zinc (p:0,05) and copper levels (p:0,0003) compared to controls. Disease severity correlated with zinc/copper ratio in COVID19 patients (p:0.018, r:-0.243). Serum zinc and Zn/Cu ratio levels had a negative relationship with acute phase markers such as IL-6, Erythrocyte Sedimentation Rate, procalcitonin and C-reactive Protein. Also, increased serum magnesium level may play a role in decreased white blood cell, neutrophil, lymphocyte cell count and increased CRP levels in the third trimester. This study indicated that trace element status changed in pregnant women with COVID-19. The effect of trace elements on pregnant women diagnosed with COVID-19 infection was investigated in comparison with healthy pregnant women for the first time. This effect will be revealed better in more comprehensive studies to be planned in the future.
Highlights
SARS CoV-2 is a novel coronavirus which has caused many deaths in the recent pandemic
This study aimed to evaluate the status of zinc, copper and magnesium in pregnant women diagnosed with SARS-CoV-2 infection by comparing with the trimester clinical outcomes of healthy pregnant women
200 pregnant women were included in this study, the number of pregnant with COVID-19 infection were 100 and the other 100 patients were healthy pregnant women
Summary
SARS CoV-2 is a novel coronavirus which has caused many deaths in the recent pandemic. This study aimed to determine zinc, copper and magnesium status on pregnant women with COVID-19. 100 healthy (33/32/35) and 100 SARS-CoV-2 positive (34/33/33) pregnant women were included in the study according to their trimesters. SARS-CoV is a virus which is capable to bind the angiotensinconverting enzyme 2 receptor that presents in several locations such as lung alveolar epithelial cells, enterocytes, endothelial cells and arterial smooth muscle cells in the human body This novel coronavirus has caused many deaths in the recent pandemic. In another systematic review study of pregnant women with COVID-19 was concluded that the adverse outcomes are not common our knowledge is still very limited about SARS-COV-2 and its effects on pregnancy [3]. The association between the zinc level in pregnancy and COVID-19 is still unclear
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