The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran

Haniye Sadat Fayazi,Ali-Sina Assadinia,Seyyede Sahere Mortazavi,Zahra Sharifhassan,Maryam Yaseri

doi:10.1186/s12902-022-00952-5

Haniye Sadat Fayazi, Ali-Sina Assadinia + Show 3 more

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https://doi.org/10.1186/s12902-022-00952-5

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Abstract

BackgroundDiabetic peripheral neuropathy (DPN) is one of the most common chronic microvascular complications in type 2 diabetes mellitus (T2DM). Hence, the present study aimed to investigate the association between Serum Uric Acid (SUA) levels and diabetic peripheral polyneuropathy in patients with type 2 diabetes.MethodsWe performed this case–control study during 2019–2020 on individuals with diabetes referring to the Razi clinic of Rasht, in the north of Iran. Polyneuropathy in patients was assessed based on the Neuropathy Disability Score (NDS), Diabetic neuropathy symptom score (DNS) scoring system, and electromyography (EMG)/nerve conduction velocity (NCV). The inclusion criterion for the control group was normal EMG/NCV. Then, the patients were assessed for SUA level and also laboratory results.ResultsIn total, 230 patients with type 2 diabetes were examined. The mean SUA level in the DPN group was significantly higher compared to the control group (6.72 ± 1.75 vs. 4.57 ± 1.49 mg/dL). With increasing the SUA, the odds of developing neuropathy increased by 2.2 times (OR = 2.2). The risk factors for diabetic polyneuropathy included gender (male) (OR = 0.347), SBP (OR = 1.1), retinopathy (OR = 3.29), and microalbuminuria (OR = 4.44). The chance of developing polyneuropathy in patients with retinopathy was 3.3 times higher than in the control group, it was 4.4 times in microalbuminuria patients.ConclusionElevated SUA level increased the chance of developing peripheral polyneuropathy in a person with type 2 diabetes. SUA levels higher than 5.25 mg / dL expose a person with type 2 diabetes to developing peripheral polyneuropathy.

Highlights

Diabetic peripheral neuropathy (DPN) is one of the most common chronic microvascular complica‐ tions in type 2 diabetes mellitus (T2DM)
This study aimed to investigate the relationship between Serum Uric Acid (SUA) levels and diabetic peripheral polyneuropathy in patients with type 2 diabetes referring to RAZI Clinic in Rasht during 2019–2020
In the present study, 230 people with type 2 diabetes were studied in two groups of patients with and without peripheral diabetic polyneuropathy

Summary

Introduction

Diabetic peripheral neuropathy (DPN) is one of the most common chronic microvascular complica‐ tions in type 2 diabetes mellitus (T2DM). Type 2 diabetes mellitus (T2DM) is associated with longterm complications resulting in cardiovascular diseases, renal failure, and nephropathy [1, 2]. It has increased health problems and become a worldwide concern [3, 4]. Type 2 DM involves 90–95% of diabetics and is more prevalent among the elderly [5, 6]. Neuropathy (DPN) is one of the most common chronic microvascular complications in progressing of T2DM to diabetic foot ulcer [6]. Previous research revealed that hyperuricemia with hyperglycemia, insulin resistance, dyslipidemia, and metabolic syndrome, all Fayazi et al BMC Endocrine Disorders (2022) 22:39 are involved in the development of diabetic neuropathy [11,12,13]

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