THE RELATION BETWEEN SERUM MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND CORONARY COLLATERAL DEVELOPMENT

Abstract

Background The degree of coronary collateral development is not same in every patient with similar degree of coronary stenosis. In animal studies monocyte chemoattractant protein-1 (MCP-1) has been found to be related to collateral vessel development. In this study we investigated whether a higher serum MCP-1 level is related to better coronary collateral vessel development in patients with stable coronary artery disease. Method Eighty-three patients with stable angina pectoris, who have at least one coronary stenosis equal to or greater than 70% at coronary angiography, were prospectively enrolled. Serum MCP-1 and vascular endothelial growth factor (VEGF) levels were studied. Coronary collateral development was graded according to the Rentrop method. Patients with grade 2–3 collateral developments were included in good collateral group and formed group I. The patients with grade 0–1 collateral developments were included in poor collateral group and formed group II. Results The serum MCP-1 level was significantly higher in good collateral group (288±277pg/ml vs. 132±64pg/ml; P<0.001). There was also a positive correlation between serum MCP-1 level and Rentrop score (r=0.39, P<0.001). The patients in the good collateral group also had a significantly higher number of coronary arteries with significant stenosis (1.7±0.7 vs. 1.4±0.6, P=0.049), and higher VEGF levels (322±147pg/ml vs. 225±161pg/ml, P=0.007). In multivariate analysis, only serum MCP-1 level (P=0.014, odds ratio: 1.01, 95% confidence interval: 1.002–1.019) was independently related to good coronary collateral development. Conclusion Higher serum MCP-1 level is related to better coronary collateral development. Coron Artery Dis 21:455–459 c 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. Coronary Artery Disease 2010, 21:455–459