Abstract
Neointima (NI) healing after implantation of drug-eluting coronary stents (DES) is often preclinically evaluated in healthy swine coronary models, which only allow limited conclusions. In this study, DES were implanted in an adult familial hypercholesterolemia (FH) swine model in order to better reproduce the range of NI responses that are seen in humans. Serial OCT imaging was performed before and after stenting, and at 28 days FU. The NI response showed a wide spectrum of strut coverage types. Higher percentages baseline plaque burden resulted in more uncovered struts and heterogeneous patterns of strut coverage, uniquely showing similarities to human responses.
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