Abstract
Aim: This study aimed to assess the relationship between HbA1c level and coronary artery disease (CAD) among non-diabetic patients. Methods: One hundred patients with acute coronary syndrome (ACS) who referred to coronary angiography were included. According to American Diabetes Association (ADA7) patients were classified into high risk group (HbA1c 5.7 – 6.4%) or low risk group (HbA1c <5.7%). The severity of CAD was assessed by Gensini score which allocates a numerical value for the degree of coronary stenosis and a multiplication factor that depends on lesion location. Results: The level of HbA1c was positively correlated with Gnsini score (r=0.35, P 05) or LVEF (r= -0.04, p>0.05). Conclusion: Among non-diabetic patients, higher HbA1c is significantly correlated with the severity of CAD. HbA1c level has a prognostic value to predict the severity of CAD among non-diabetic patients.
Highlights
The severity of coronary artery disease (CAD) was assessed by Gensini score which allocates a numerical value for the degree of coronary stenosis and a multiplication factor that depends on lesion location
High normal fasting blood glucose plus increased hemoglobin A1c (HbA1c) levels in non diabetics considered as potent risk factors for cardiovascular events(2)
Glycated hemoglobin values reflect two to three months average endogenous exposure to glucose including postprandial spikes in blood glucose level and have low intra-individual variability in non-diabetic patients (3).New clinical practice recommendation from the American Diabetes Association (ADA) advocates the use of HbA1c in diagnosis of diabetes mellitus largely on the basis of the established association between Glycated hemoglobin and microvascular disease (4).Levels of HbA1c less than 7% deemed appropriate for reducing risk of vascular complications(5)
Summary
The Relation between Glycated Hemoglobin and Severity of Coronary Artery Disease in Non-Diabetic Patients with acute coronary syndrome. Bastawesy*, Ahmed Abdelmoniem, , Mohamed Abdelkader and Reda Ismaiel. Cardiology Department, Faculty of Medicine, Banha Universiry, Egypt
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